5y06

Publication Abstract from PubMed

The MSMEG_4306 gene from Mycobacterium smegmatis encodes a protein of unknown function with 242 amino-acid residues that contains a conserved zinc-ribbon domain at its C-terminus. Here, the crystal structure of MSMEG_4306 determined by the single-wavelength anomalous dispersion method using just one zinc ion co-purified with the protein is reported. The crystal structure of MSMEG_4306 shows a coiled-coil helix domain in the N-terminal region and a zinc-ribbon domain in the C-terminal region. A structural similarity search against the Protein Data Bank using MSMEG_4306 as a query revealed two similar structures, namely CT398 from Chlamydia trachomatis and HP0958 from Helicobacter pylori, although they share only approximately 15% sequence identity with MSMEG_4306. Based on comparative analysis, it is predicted that MSMEG_4306 may be involved in secretion systems, possibly by interacting with multiple proteins or nucleic acids.

Crystal structure of the MSMEG_4306 gene product from Mycobacterium smegmatis.,Kumar A, Karthikeyan S Acta Crystallogr F Struct Biol Commun. 2018 Mar 1;74(Pt 3):166-173. doi:, 10.1107/S2053230X18002236. Epub 2018 Feb 26. PMID:29497021^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.