Stimulator of interferon genes

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spinqualitylabelsall models Structure of human STING CTD complex with c-GMP-AMP (PDB entry 4loh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Stimulator of interferon genes (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling[1]. Structural highlights The [2]. Water molecules are shown as red spheres.

3D structures of STING

(Updated on 09-November-2020

References

1. ↑ Poltorak A, Kurmyshkina O, Volkova T. Stimulator of interferon genes (STING): A "new chapter" in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity. Cytokine Growth Factor Rev. 2016 Jun;29:83-91. doi:, 10.1016/j.cytogfr.2016.02.009. Epub 2016 Mar 4. PMID:26980676 doi:http://dx.doi.org/10.1016/j.cytogfr.2016.02.009
2. ↑ Gao P, Ascano M, Zillinger T, Wang W, Dai P, Serganov AA, Gaffney BL, Shuman S, Jones RA, Deng L, Hartmann G, Barchet W, Tuschl T, Patel DJ. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell. 2013 Aug 15;154(4):748-62. doi: 10.1016/j.cell.2013.07.023. Epub 2013 Aug, 1. PMID:23910378 doi:10.1016/j.cell.2013.07.023