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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function of your Protein
are cell wall proteins responsible for for the binding of a bacteria or fungi to its host. My epithelial adhesin is part of the Candida glabrata, Candidiasis are any type of fungal infections resulting from Yeast (candida). Their N-terminal domains are endowed with a calcium-dependent lectin activity. This feature allows the yeast cells to adhere to host cells by establishing multiple interactions with the glycans expressed on their cell membrane. My Protein binds to . Once the fungi binds to its host it can then release enzymes through its hyphae that help it absorb nutrients from the host.
Biological relevance and broader implications
Epithelial Adhesins are important for fungi because they help the organism bind to the host so they can live, gain nurtrients and maintain its steady state. Candida Glabrata which house these epithelial adhesins are the 2nd major cause of clinical candidias, It is most prevelant in vaginal infections but can even cause systemic infections by entrance of the fungal cells in the bloodstream (Candidemia), especially prevalent in immunocompromised patients. it is important to study protiens like epithelial adhesins so we can better understand how fungi and other organisms infect the body, ny undertanding the role of these protiens we can begin to work on combat methods and long term immunity.
Important amino acids
i: DcisD = DD or asp 196,197 hydrogen bond with Gal b, metal interactions
with Ca+ that also has metal interactions with Gal b
ii: Asn 241 is asparagine has metal interactions with ca+ and Gal b
iii: Asp 243 metal interaction with gal b
iv: Arginine 242 hydrogen bonds with ligand gal b, cation pi interactions with
trp 95
v: His 245 has metal interactions with Gal b
vi: Cys 136 and 94 disulfide bond and hydrogen bond with N-acetyl-d-
glucosamine (GlcNAc)
Structural highlights
My protein is a epithelial adhesin protein binded to a Galactose beta 1-3 N-acetyl-D-Glucosamine, it contains 3 to 5 small alpha helices and a core of anti parralel beta sheets also known as the beta sandwich core. all of the important catalytic amino acids bind to the ligand by hydrogen bonds with the ligand itself or metal interaction with Ca+ its also contains a disulfide bond binding two loops together that are crucial in ligand affinity. It also contains two loops connected by a disulfide bond that play a key role in ligand affinity when these are changed the protien often accepts a different carbohydrate ligand
Other important features
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