Sandbox Reserved 1660

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This Sandbox is Reserved from 26/11/2020, through 26/11/2021 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1643 through Sandbox Reserved 1664.

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spinqualitylabelsall models Structure of mouse CD1d expressed in SF9 cells, no ligand added (PDB entry 3GMQ) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structure of mouse CD1d expressed in SF9 cells, no ligand added

CD1 (Cluster of Differentiation 1) is a family of glycoproteins involved in the presentation of antigens on the surface of specific cells to NKT cells. Amongst these CD1-presenting cells can be counted splenic dendritic cells, marginal zone B cells and CD4+CD8+ thymocytes. This family is made of two main groups: group 1 is composed of CD1a, b and c proteins and group 2 is composed of CD1d proteins.
Thus, the structure and function of such proteins in mice are akin to those of humans. Mice doesn’t express group 1 CD1 molecules. Instead, they have two kinds of CD1d molecules. Therefore, they have been widely used to characterize the functions of CD1d and CD1d-dependent NKT cells in many diseases.

Contents 1 Structure of mouse CD1d expressed in SF9 cells, no ligand added 2 Function 3 Structure 4 Impact of ligand-binding 5 Appications 6 See Also 7 References

Function

Structure

Impact of ligand-binding

Appications

See Also

• CD1

References

^[1]