Structural highlights
Function
[IL22_HUMAN] Cytokine that contributes to the inflammatory response in vivo.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The crystal structure of interleukin-22 expressed in Drosophila melanogaster S2 cells (IL-22(Dm)) has been determined at 2.6 A resolution. IL-22(Dm) crystals contain six molecules in the asymmetric unit. Comparison of IL-22(Dm) and IL-22(Ec) (interleukin-22 produced in Escherichia coli) structures reveals that N-linked glycosylation causes only minor structural changes to the cytokine. However, 1-4 A main-chain differences are observed between the six IL-22(Dm) monomers at regions corresponding to the IL-22R1 and IL-10R2 binding sites. The structure of the carbohydrate and the conformational variation of IL22(Dm) provide new insights into IL-22 receptor recognition.
Structure of insect-cell-derived IL-22.,Xu T, Logsdon NJ, Walter MR Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Xu T, Logsdon NJ, Walter MR. Structure of insect-cell-derived IL-22. Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):942-50. Epub 2005, Jun 24. PMID:15983417 doi:10.1107/S0907444905009601
