TRAP dicarboxylate transporter, DctP subunit

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spinqualitylabelsall models Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code 1ksx) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function TRAP dicarboxylate transporter, DctP subunit [1]. Disease RPE1 has been shown to mitigate host cell defenses leading to the development of cancer induces apoptosis of its host cells[2]. Relevance The detection of RPE1 mRNA and promoter methylation may serve as cancer prognostic marker. Structural highlights The complex between BPV1 DBD and 21-bp DNA (PDB code 1ksx) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones[3].

Contents 1 3D structures of TRAP dicarboxylate transporter, DctP subunit 2 References 3 Your Heading Here (maybe something like 'Structure') 4 References

3D structures of TRAP dicarboxylate transporter, DctP subunit

Updated on 31-January-2021

Domains: helicase 301-605; DNA-binding (DBD) 286-365

4n6d - DsDctP - Desulfovibrio salexigens
4n6k - DsDctP + diglycerolphosphate
4mco - DctP + malonate - Rhodoferax ferrireducens
4ovt - DctP + fuconate - Ochtrobactrum anthropi
5cm6 - DctP + pyruvate - Pseudoalteromonas atlantica
4n91 - DctP + glucoronate - Anaerococcus prevotii
4n8g - DctP + Ala-Ala - Chromohalobacter salexigens

References

1. ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
2. ↑ Baedyananda F, Chaiwongkot A, Bhattarakosol P. Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression. Intervirology. 2017;60(5):171-180. doi: 10.1159/000487048. Epub 2018 Mar 1. PMID:29495005 doi:http://dx.doi.org/10.1159/000487048
3. ↑ Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. EMBO J. 2002 Mar 15;21(6):1487-96. PMID:11889054 doi:http://dx.doi.org/10.1093/emboj/21.6.1487

Your Heading Here (maybe something like 'Structure')

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image This is a default text for your page TRAP dicarboxylate transporter, DctP subunit. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Disease Relevance Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644