TRAP dicarboxylate transporter, DctP subunit

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spinqualitylabelsall models Bovine papillomavirus 1 replication protein E1 complex with DNA (PDB code 4mhf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function TRAP dicarboxylate transporter, DctP subunit [1]. Disease RPE1 has been shown to mitigate host cell defenses leading to the development of cancer induces apoptosis of its host cells[2]. Relevance The detection of RPE1 mRNA and promoter methylation may serve as cancer prognostic marker. Structural highlights The complex between BPV1 DBD and 21-bp DNA (PDB code 1ksx) shows 2 DBD-DNA binding modules: a binding loop and a binding helix each interacting with a single strand. The protein-DNA interactions are hydrophilic to phosphate atoms and van der Waals hydrophobic ones[3].

3D structures of TRAP dicarboxylate transporter, DctP subunit

Updated on 31-January-2021

References

1. ↑ Wilson VG, West M, Woytek K, Rangasamy D. Papillomavirus E1 proteins: form, function, and features. Virus Genes. 2002 Jun;24(3):275-90. doi: 10.1023/a:1015336817836. PMID:12086149 doi:http://dx.doi.org/10.1023/a:1015336817836
2. ↑ Baedyananda F, Chaiwongkot A, Bhattarakosol P. Elevated HPV16 E1 Expression Is Associated with Cervical Cancer Progression. Intervirology. 2017;60(5):171-180. doi: 10.1159/000487048. Epub 2018 Mar 1. PMID:29495005 doi:http://dx.doi.org/10.1159/000487048
3. ↑ Enemark EJ, Stenlund A, Joshua-Tor L. Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex. EMBO J. 2002 Mar 15;21(6):1487-96. PMID:11889054 doi:http://dx.doi.org/10.1093/emboj/21.6.1487