PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of genes specific to myeloid and lymphoid cells, ultimately leading to cellular differentiation.
Name and Location
The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence.
The protein resides in the nucleus.
Binding Domain
Ets binding domain is conserved across the Ets family of proteins.
Binding domain is positively charged. Residues most closely interacting with DNA include Arginine and Lysine.
Disease
PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site.
PEST domain
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
