Structural highlights
Function
[HCFC1_MOUSE] Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.[1] [2]
References
- ↑ Kristie TM. The mouse homologue of the human transcription factor C1 (host cell factor). Conservation of forms and function. J Biol Chem. 1997 Oct 17;272(42):26749-55. PMID:9334261
- ↑ Kristie TM, Vogel JL, Sears AE. Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1229-33. PMID:9990006
