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Nuclear receptor structure is composed of 5 domains -
A/B: N-terminal regulatory domain contains activation function 1 (residues 101-370), activation function 5 (residues 360-485) and dimerization surface (residues 1-36 and 370-494).
C: DNA binding domain (DBD)
D: Hinge region between DBD and LBD
E: Ligand binding domain (LBD) containing an which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif (Human androgen receptor ligand-binding domain complex with modulator; PDB code 3b5r).[1] Water molecules are shown as red spheres.
F: C-terminal domain
See also Receptor
Family members (~ according to [1]):
Thyroid Hormone Receptor-like
Thyroid hormone receptor
Retinoic acid receptor
PPARγ
Liver X receptor-like
Vitamin D receptor-like
- When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA (see below).
Retinoid X Receptor-like
Retinoid X receptor
Estrogen Receptor-like
Estrogen receptor
Estrogen receptor alpha
Estrogen receptor beta
3-Ketosteroid receptors
