Function
Cystathionine β-lyase (CBL) belongs to a family of PLP-dependent enzymes which cleave C β-S bonds in a variety of subtsrates. CBL catalyzes a reaction specific for methionine biosynthesis[1]. CBL converts L-cystathionine to L-homocysteine, pyruvate and ammonia.
Structural highlights
The structure of the EcCBL shows 3 spatially different domains. The (residues 1-60) contributes to the . The (residues 61-256) binds to the PLP and the (residues 257-395). and mediates the proton transfer between Cα and Sγ[2]. .