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Thioether protein crosslinks

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Revision as of 20:04, 4 July 2021 by Eric Martz (Talk | contribs)
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Thioether bonds between cysteine and tyrosine have been well studied in cysteine dioxygenases[1]. Thioether bonds between cysteine and the vinyl groups of hemes are common. Diverse other ligands are bonded to protein via cysteine thioether linkages.

An accurate estimate of the frequency of thioethers in the PDB may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character PDB codes.

Contents

Examples

Cys-Tyr

  • 6e87 (2019): Cysteine dioxygenase.

Cys-Ligand

References

  1. ↑ Davies CG, Fellner M, Tchesnokov EP, Wilbanks SM, Jameson GN. The Cys-Tyr Crosslink of Cysteine Dioxygenase changes the Optimum pH of Reaction without Structural Change. Biochemistry. 2014 Nov 12. PMID:25390690 doi:http://dx.doi.org/10.1021/bi501277a

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Eric Martz

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