Thioether protein crosslinks

From Proteopedia

Revision as of 20:12, 4 July 2021 by Eric Martz (Talk | contribs)
Jump to: navigation, search

Thioether bonds between the sidechains of cysteine and tyrosine have been well studied in cysteine dioxygenases[1]. Thioether bonds between cysteine and the vinyl groups of hemes are common. Diverse other ligands are bonded to protein via cysteine thioether linkages. (Note that the sidechain of methionine contains a thioether.)

An accurate estimate of the frequency of thioethers in the PDB may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character PDB codes.

Contents

Examples

Cys-Tyr

  • 6e87 (2019): Cysteine dioxygenase.

Cys-Ligand

References

  1. ↑ Davies CG, Fellner M, Tchesnokov EP, Wilbanks SM, Jameson GN. The Cys-Tyr Crosslink of Cysteine Dioxygenase changes the Optimum pH of Reaction without Structural Change. Biochemistry. 2014 Nov 12. PMID:25390690 doi:http://dx.doi.org/10.1021/bi501277a

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

Retrieved from "http://52.214.119.220/wiki/index.php/Thioether_protein_crosslinks"
Personal tools