Structural highlights
Function
[ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.[1]
Publication Abstract from PubMed
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase.,Wei X, Schultz K, Bazilevsky GA, Vogt A, Marmorstein R Nat Struct Mol Biol. 2020 May;27(5):511-513. doi: 10.1038/s41594-020-0421-9. PMID:32242119[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lin R, Tao R, Gao X, Li T, Zhou X, Guan KL, Xiong Y, Lei QY. Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth. Mol Cell. 2013 Aug 22;51(4):506-18. doi: 10.1016/j.molcel.2013.07.002. Epub 2013 , Aug 8. PMID:23932781 doi:http://dx.doi.org/10.1016/j.molcel.2013.07.002
- ↑ Wei X, Schultz K, Bazilevsky GA, Vogt A, Marmorstein R. Author Correction: Molecular basis for acetyl-CoA production by ATP-citrate lyase. Nat Struct Mol Biol. 2020 May;27(5):511-513. doi: 10.1038/s41594-020-0421-9. PMID:32242119 doi:http://dx.doi.org/10.1038/s41594-020-0421-9
