Structural highlights
3f0v is a 1 chain structure with sequence from Staab. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 3f0b, 3f0q, 3f0s, 3f0u, 3f0x |
| Gene: | dfrB (STAAB) |
| Activity: | Dihydrofolate reductase, with EC number 1.5.1.3 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[Q2YY41_STAAB] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
