Structural highlights
Function
[6PGD_SHEEP] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The three-dimensional structure of ovine 6-phosphogluconate dehydrogenase, refined at 2.5 A resolution with a residual for all data of 18.5%, is reported. This model, based on improved diffraction data and a corrected sequence, supersedes that reported earlier. Each subunit of the dimer has three domains: a beta-alpha-beta domain binds NADP; an all alpha domain provides much of the dimer interface; the C-terminal tail burrows into the second subunit.
The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution.,Adams MJ, Gover S, Leaback R, Phillips C, Somers DO Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):817-20. PMID:1793548[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Adams MJ, Gover S, Leaback R, Phillips C, Somers DO. The structure of 6-phosphogluconate dehydrogenase refined at 2.5 A resolution. Acta Crystallogr B. 1991 Oct 1;47 ( Pt 5):817-20. PMID:1793548
