3afo

Structural highlights

Function

[POS5_YEAST] Phosphorylates both NADH and NAD(+), with a twofold preference for NADH. Anti-oxidant factor and key source of the cellular reductant NADPH.^{[1] [2]}

References

1. ↑ Outten CE, Culotta VC. A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae. EMBO J. 2003 May 1;22(9):2015-24. PMID:12727869 doi:http://dx.doi.org/10.1093/emboj/cdg211
2. ↑ Strand MK, Stuart GR, Longley MJ, Graziewicz MA, Dominick OC, Copeland WC. POS5 gene of Saccharomyces cerevisiae encodes a mitochondrial NADH kinase required for stability of mitochondrial DNA. Eukaryot Cell. 2003 Aug;2(4):809-20. PMID:12912900