Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The major 97-aa timothy grass (Phleum pratense) allergen Phl p 3 was recently isolated from an extract of timothy grass pollen. Sequence comparison classifies this protein as a group 3 allergen. The solution structure of Phl p 3 as determined by nuclear magnetic resonance spectroscopy reveals that the protein consists of a core of hydrophobic amino-acid side chains from two beta-sheets of five and four anti-parallel beta-strands, respectively. This conformation is very similar to the crystal structure published for Phl p 2 and strongly resembles the known conformation of the carboxy-terminal domain of Phl p 1, the major difference being the loop orientations. Phl p 2 and Phl p 3 show virtually identical immunoreactivity, and comparison of the charged surface amino acids of the two proteins gives initial clues as to the IgE recognition epitopes of these proteins.
Solution structure of Phl p 3, a major allergen from timothy grass pollen.,Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I Biol Chem. 2008 Jul;389(7):919-23. PMID:18627309[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Schweimer K, Petersen A, Suck R, Becker WM, Rosch P, Matecko I. Solution structure of Phl p 3, a major allergen from timothy grass pollen. Biol Chem. 2008 Jul;389(7):919-23. PMID:18627309 doi:10.1515/BC.2008.102
