2mgn

Publication Abstract from PubMed

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive pi-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation.

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3.,Chung WJ, Heddi B, Hamon F, Teulade-Fichou MP, Phan AT Angew Chem Int Ed Engl. 2014 Jan 20;53(4):999-1002. doi: 10.1002/anie.201308063. , Epub 2013 Dec 16. PMID:24356977^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.