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Contents 1 Methionine adenosyltransferase 1.1 SAM Formation Mechanism 1.2 Function 1.3 Structure 1.4 References

Methionine adenosyltransferase

MAT synthesizes S-adenosylmethionine from the substrates ATP and methionine. ATP isn’t used as a source of energy like it is in other reactions but gets a methionine added onto the 5th carbon while the three phosphate groups are broken down and released from the active sit. This enzyme is conserved and found in many organisms, so it is essential for life. Problems with this enzyme have been shown to cause diseases such as various cancers.

SAM Formation Mechanism

Function

Structure

spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image MAT consists of α and β subunits. MATα1 and MATα2 are catalytic subunits while MATβ is a regulatory subunit. The subunits are encoded on different genes in humans, so they are created separately and can then come together to form various complexes, such as MATαβ or MATα2 dimers [1] Other Substrates Relevance

References

1. ↑ Murray et al.