User:Michael O'Shaughnessy/ TS

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Overview

The enzyme thymidylate synthase catalyzes the transfer of a methyl group and a hydride from 5,10-methylenetetrahydrofolate to 2-deoxyuridine-5'-monophosphate, resulting in the formation of thymidine 5'-monophosphate and dihydrofolate. This is the only de novo source of dTMP in humans.

2-deoxyuridine-5'-monophosphate(dUMP) + 5, 10-methylenetetrahydrofolate(CH₂H₄F) ⇌ thymidine 5'-monophosphate(dTMP) + Dihydrofolate(H₂F)

Small Molecules

2-deoxyuridine-5'-monophosphate(dUMP)

5,10-methylenetetrahydrofolate(CH₂H₄F)

thymidine 5'-monophosphate(dTMP)

Dihydrofolate(H₂F)

Mechanism

Function

Disease

Relevance

Structural highlights

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