Structural highlights
4qgn is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| Gene: | ADI1, HMFT1638, MTCBP1, NP_060739 (HUMAN) |
| Activity: | Acireductone dioxygenase (Fe(2+)-requiring), with EC number 1.13.11.54 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[MTND_HUMAN] Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.[HAMAP-Rule:MF_03154][1] [2]
References
- ↑ Yeh CT, Lai HY, Chen TC, Chu CM, Liaw YF. Identification of a hepatic factor capable of supporting hepatitis C virus replication in a nonpermissive cell line. J Virol. 2001 Nov;75(22):11017-24. PMID:11602742 doi:http://dx.doi.org/10.1128/JVI.75.22.11017-11024.2001
- ↑ Hirano W, Gotoh I, Uekita T, Seiki M. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Genes Cells. 2005 Jun;10(6):565-74. PMID:15938715 doi:http://dx.doi.org/10.1111/j.1365-2443.2005.00859.x
