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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Introduction

Titin, (TITN) also known as Connectin (PDB 3b43) is a human protein, unique for its large size. It is the largest known protein chain in the entire human body, comprising over 34,000 amino acids and holding a molecular weight of 3800 kD. Titin is found within muscle fibers and classified as a connectin protein. An adult human that weighs 80 kg may contain almost half a kilogram of Titin, making it extremely abundant as well. ^[3] Due to its abundance and overall importance to human musculature Titin is exceedingly important and vital to understand.

Test 2 ^[3]

Discovery

The discovery of Titin first began in 1949 as the Australian scientists -- Draper and Hodge -- announced their findings of the first high resolution electron microscope images of striated muscle. (Dos Remedios). From this imaging it was theorized that there were three strands that comprise striated muscles, but after a multitude of papers began to be published on the two filament theory, it quickly became widely accepted. It took until 1986 for the advancement of Atomic Force Microscopy to fully differentiate and view the large protein which was measured to be greater than 10^6 Da and longer than 1 micrometer. ^[4] This idea is interesting although Titin had been imaged for more than 30 years before it was officially identified and named. It seemingly was ignored due to the popularity of a two filament system as the Actin and Myosin slide and pull over each other. It is now known that Titin is a structural aid that helps with elasticity, although it technically is the ‘third filament.’

Structure

Function

Medical Importance

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