NKX2.5 Homeodomain

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NKX2.5 Homeodomain

PDB ID 3RKQ

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References

  1. ↑ Gehring WJ, Affolter M, Burglin T. Homeodomain proteins. Annu Rev Biochem. 1994;63:487–526.
  2. ↑ Bürglin, T. R., & Affolter, M. (2016). Homeodomain proteins: an update. Chromosoma, 125(3), 497–521. https://doi.org/10.1007/s00412-015-0543-8
  3. ↑ Olson, E. N. (2006) Gene regulatory networks in the evolution and development of the heart. Science 313, 1922−1927.
  4. ↑ Akazawa H, Komuro I. Cardiac transcription factor Csx/Nkx2–5: Its role in cardiac development and diseases. Pharmacol Ther. 2005;107:252–268.
  5. ↑ Toko, H., Zhu, W., Takimoto, E., Shiojima, I., Hiroi, Y., Zou, Y., Oka, T., Akazawa, H., Mizukami, M., Sakamoto, M., Terasaki, F., Kitaura, Y., Takano, H., Nagai, T., Nagai, R., and Komuro, I. (2002) Csx/Nkx2−5 is required for homeostasis and survival of cardiac myocytes in the adult heart. J. Biol. Chem. 277, 24735−24743.
  6. ↑ Schott, J., Benson, D., Basson, C., Pease, W., Silberbach, G., Moak, J., Maron, B., Seidman, C., and Seidman, J. (1998) Congenital heart disease caused by mutations in the transcription factor NKX2−5. Science 281, 108−111.
  7. ↑ McElhinney, D. B., Geiger, E., Blinder, J., Benson, D. W., & Goldmuntz, E. (2003). NKX2.5 mutations in patients with congenital heart disease. Journal of the American College of Cardiology, 42(9), 1650–1655. https://doi.org/10.1016/j.jacc.2003.05.004

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