7mk2

Structural highlights

Function

[NPR1_ARATH] May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.^{[1] [2] [3] [4] [5] [6] [7]}

References

1. ↑ Delaney TP, Friedrich L, Ryals JA. Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6602-6. doi: 10.1073/pnas.92.14.6602. PMID:11607555 doi:http://dx.doi.org/10.1073/pnas.92.14.6602
2. ↑ Spoel SH, Koornneef A, Claessens SM, Korzelius JP, Van Pelt JA, Mueller MJ, Buchala AJ, Metraux JP, Brown R, Kazan K, Van Loon LC, Dong X, Pieterse CM. NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. Plant Cell. 2003 Mar;15(3):760-70. doi: 10.1105/tpc.009159. PMID:12615947 doi:http://dx.doi.org/10.1105/tpc.009159
3. ↑ Mou Z, Fan W, Dong X. Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes. Cell. 2003 Jun 27;113(7):935-44. doi: 10.1016/s0092-8674(03)00429-x. PMID:12837250 doi:http://dx.doi.org/10.1016/s0092-8674(03)00429-x
4. ↑ Johnson C, Boden E, Arias J. Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis. Plant Cell. 2003 Aug;15(8):1846-58. PMID:12897257
5. ↑ Despres C, Chubak C, Rochon A, Clark R, Bethune T, Desveaux D, Fobert PR. The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1. Plant Cell. 2003 Sep;15(9):2181-91. doi: 10.1105/tpc.012849. PMID:12953119 doi:http://dx.doi.org/10.1105/tpc.012849
6. ↑ Shah J, Tsui F, Klessig DF. Characterization of a salicylic acid-insensitive mutant (sai1) of Arabidopsis thaliana, identified in a selective screen utilizing the SA-inducible expression of the tms2 gene. Mol Plant Microbe Interact. 1997 Jan;10(1):69-78. doi: 10.1094/MPMI.1997.10.1.69. PMID:9002272 doi:http://dx.doi.org/10.1094/MPMI.1997.10.1.69
7. ↑ Cao H, Glazebrook J, Clarke JD, Volko S, Dong X. The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell. 1997 Jan 10;88(1):57-63. PMID:9019406