7zee

Structural highlights

Function

[5NT3B_HUMAN] Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).^{[1] [2]}

References

1. ↑ Buschmann J, Moritz B, Jeske M, Lilie H, Schierhorn A, Wahle E. Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J Biol Chem. 2013 Jan 25;288(4):2441-51. doi: 10.1074/jbc.M112.426700. Epub 2012 , Dec 5. PMID:23223233 doi:http://dx.doi.org/10.1074/jbc.M112.426700
2. ↑ Monecke T, Buschmann J, Neumann P, Wahle E, Ficner R. Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP. PLoS One. 2014 Mar 6;9(3):e90915. doi: 10.1371/journal.pone.0090915. eCollection , 2014. PMID:24603684 doi:http://dx.doi.org/10.1371/journal.pone.0090915