Structural highlights
Publication Abstract from PubMed
We report here the crystal structure of the partially self-complementary decameric sequence d(CGGCGGCCGC), which self assembles to form a four-way junction with sticky ends. Each junction binds to four others through Watson-Crick base pairing at the sticky ends to form a rhombic structure. The rhombuses bind to each other and form two dimensional tiles. The tiles stack to form the crystal. The crystal diffracted in the space group P1 to a resolution of 2.5A. The junction has the anti-parallel stacked-X conformation like other junction structures, though the formation of the rhombic net noticeably alters the details of the junction geometry.
The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA lattice.,Venkadesh S, Mandal PK, Gautham N Biochem Biophys Res Commun. 2011 Apr 15;407(3):548-51. Epub 2011 Mar 16. PMID:21419105[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Venkadesh S, Mandal PK, Gautham N. The sequence d(CGGCGGCCGC) self-assembles into a two dimensional rhombic DNA lattice. Biochem Biophys Res Commun. 2011 Apr 15;407(3):548-51. Epub 2011 Mar 16. PMID:21419105 doi:10.1016/j.bbrc.2011.03.056
