Crystal structure determination of the halogenase CtcP from Streptomyces aureofaciens
Lijuan Yin [1]
Molecular Tour
The crystal structure of selenomethionine-derivatised Streptomyces aureofaciens halogenase CtcP, which functions in chlortetracycline biosynthesis, is reported here at 2.7 Å resolution. The structure reveals a conserved monooxygenase domain and a unique C-terminal domain. Although FAD is not observed in the structure, the monooxygenase domain has a conserved FAD-binding pocket and an active center.
References
- ↑ Yin L. Crystal structure determination of the halogenase CtcP from Streptomyces aureofaciens. Acta Crystallogr F Struct Biol Commun. 2022 Jul 1;78(Pt 7):270-275. doi:, 10.1107/S2053230X22006586. Epub 2022 Jul 4. PMID:35787554 doi:http://dx.doi.org/10.1107/S2053230X22006586
