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Factor XII

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Glycosylated human factor XII protease domain (deep sky blue) complex with cyclic peptide inhibitor (green)

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References

  1. Renne T, Schmaier AH, Nickel KF, Blomback M, Maas C. In vivo roles of factor XII. Blood. 2012 Nov 22;120(22):4296-303. doi: 10.1182/blood-2012-07-292094. Epub 2012, Sep 19. PMID:22993391 doi:http://dx.doi.org/10.1182/blood-2012-07-292094
  2. Nickel KF, Long AT, Fuchs TA, Butler LM, Renne T. Factor XII as a Therapeutic Target in Thromboembolic and Inflammatory Diseases. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):13-20. doi:, 10.1161/ATVBAHA.116.308595. Epub 2016 Nov 10. PMID:27834692 doi:http://dx.doi.org/10.1161/ATVBAHA.116.308595
  3. Liu W, de Veer SJ, Huang YH, Sengoku T, Okada C, Ogata K, Zdenek CN, Fry BG, Swedberg JE, Passioura T, Craik DJ, Suga H. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489. doi: 10.1021/jacs.1c07574. Epub, 2021 Nov 1. PMID:34723512 doi:http://dx.doi.org/10.1021/jacs.1c07574

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