CAD protein

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CAD protein dihydroorotatase subunit complex with dihydroorotate, carbamoyl aspartate, format and Zn+2 ions (PDB ID 4c6d)

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References

↑ Moreno-Morcillo M, Grande-Garcia A, Ruiz-Ramos A, Del Cano-Ochoa F, Boskovic J, Ramon-Maiques S. Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis. Structure. 2017 Jun 6;25(6):912-923.e5. doi: 10.1016/j.str.2017.04.012. Epub 2017, May 25. PMID:28552578 doi:http://dx.doi.org/10.1016/j.str.2017.04.012
↑ Ng BG, Wolfe LA, Ichikawa M, Markello T, He M, Tifft CJ, Gahl WA, Freeze HH. Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors. Hum Mol Genet. 2015 Jun 1;24(11):3050-7. doi: 10.1093/hmg/ddv057. Epub 2015 Feb, 12. PMID:25678555 doi:http://dx.doi.org/10.1093/hmg/ddv057