Function
Phytase (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate [1]. PHYT are a subclass of the histidine acid phosphatase[2]. Phytate is the main phosphorus storage system in plant seeds. Phytate is indigestible by monogastric animals and humans[3].
Relevance
PHYT is found in plant material and is used to increase the nutritional quality of grains, legumes, seeds and corn. PHYT is used as a dietary supplement in broiler nutrition[4]. Studies show that supplementing PHYT can reduce the need for calcium phosphate and increase digestive health.
Structural highlights
The 3D structure of the complex between phytase and myo-inositol hexakisphosphate shows the extensive contacts of the phosphoryl groups of the substrate binding in the highly basic binding pocket[5].
3D structures of phytase
Phytase 3D structures