Function
Guanylate cyclase. (GC) catalyse the conversion of GTP to cGMP and pyrophosphate. cGMP is a messenger that modulates various processes like platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure and more[1].
Disease
Relevance
A GC activator - Cinaciguat - is investigated as add-on to therapy of patients suffering from acute heart failure syndrome[2], [3].
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
