User:Snehalatha Kaliappan/Histamine

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Structure of Histamine

Histamine is an organic compound containing nitrogen atoms found in some of the human body cells. It is part of the immune system that causes the allergy related symptoms such as itching, sneezing and cold like symptoms. It also acts like a neurotransmitter in brain, spinal cord and uterus. It also regulates physiological functions in gut. The imidazole ring of the histamine can have two tautomeric forms depending on which of the two nitrogens' is protonated. The nitrogen farther away from the side chain is the 'tele' nitrogen and is denoted by a lowercase tau sign and the nitrogen closer to the side chain is the 'pros' nitrogen and is denoted by the pi sign. The tele tautomer, Nτ-H-histamine, is preferred in solution as compared to the pros tautomer, Nπ-H-histamine.

Histamine H1 Receptor

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Structure of the human histamine H1 receptor in complex with doxepin.

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