Structural highlights
4alo is a 2 chain structure with sequence from American lobster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 1h91, 1i4u, 1obq, 1obu, 1s2p |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CRC1_HOMGA] Binds the carotenoid astaxanthin (AXT) which provides the blue coloration to the carapace of the lobster.
Publication Abstract from PubMed
Crustacean crustacyanin proteins are linked to the production and modification of carapace colour, with direct implications for fitness and survival. Here, the structural and functional properties of the two recombinant crustacyanin subunits H(1) and H(2) from the American lobster Homarus americanus are reported. The two subunits are structurally highly similar to the corresponding natural apo crustacyanin CRTC and CRTA subunits from the European lobster H. gammarus. Reconstitution studies of the recombinant crustacyanin proteins H(1) and H(2) with astaxanthin reproduced the bathochromic shift of 85-95 nm typical of the natural crustacyanin subunits from H. gammarus in complex with astaxanthin. Moreover, correlations between the presence of crustacyanin genes in crustacean species and the resulting carapace colours with the spectral properties of the subunits in complex with astaxanthin confirmed this genotype-phenotype linkage.
Structural characterization of recombinant crustacyanin subunits from the lobster Homarus americanus.,Ferrari M, Folli C, Pincolini E, McClintock TS, Rossle M, Berni R, Cianci M Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):846-53., Epub 2012 Jul 26. PMID:22869108[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Ferrari M, Folli C, Pincolini E, McClintock TS, Rossle M, Berni R, Cianci M. Structural characterization of recombinant crustacyanin subunits from the lobster Homarus americanus. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Aug 1;68(Pt 8):846-53., Epub 2012 Jul 26. PMID:22869108 doi:10.1107/S1744309112026103
