Structural highlights
4cwd is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| Activity: | Gamma-butyrobetaine dioxygenase, with EC number 1.14.11.1 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[BODG_HUMAN] Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Publication Abstract from PubMed
gamma-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.
Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids.,Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125., Epub 2014 Aug 27. PMID:25164544[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Rydzik AM, Leung IK, Kochan GT, McDonough MA, Claridge TD, Schofield CJ. Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl-piperidine-4-carboxylic Acids. Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10925-7. doi: 10.1002/anie.201406125., Epub 2014 Aug 27. PMID:25164544 doi:http://dx.doi.org/10.1002/anie.201406125
