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1ih6
From Proteopedia
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| , resolution 1.45Å | |||||||
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| Ligands: | , , | ||||||
| Related: | 1IH1, 1IH2, 1IH3, 1IH4
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Multi-Conformation Crystal Structure of GGBr5CGCC
Overview
The transition between B- and A-DNA was first observed nearly 50 years ago. We have now mapped this transformation through a set of single-crystal structures of the sequence d(GGCGCC)2, with various intermediates being trapped by methylating or brominating the cytosine bases. The resulting pathway progresses through 13 conformational steps, with a composite structure that pairs A-nucleotides with complementary B-nucleotides serving as a distinct transition intermediate. The details of each step in the conversion of B- to A-DNA are thus revealed at the atomic level, placing intermediates for this and other sequences in the context of a common pathway.
About this Structure
1IH6 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
A crystallographic map of the transition from B-DNA to A-DNA., Vargason JM, Henderson K, Ho PS, Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7265-70. Epub 2001 Jun 5. PMID:11390969
Page seeded by OCA on Sun Mar 30 21:19:42 2008
