Structural highlights
4doh is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Ligands: | |
| Gene: | IL20, ZCYTO10, UNQ852/PRO1801 (HUMAN), IL20RB, DIRS1, UNQ557/PRO1114 (HUMAN), IL20RA, UNQ681/PRO1315 (HUMAN) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[IL20_HUMAN] Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3. [I20RA_HUMAN] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26. [I20RB_HUMAN] The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
Publication Abstract from PubMed
Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines IL-19 and IL-24, designated IL-20 subfamily cytokines (IL-20SFCs), induce cellular responses through an IL-20R1/IL-20R2 (type I) receptor heterodimer, whereas IL-20 and IL-24 also signal through the IL-22R1/IL-20R2 (type II) receptor complex. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands. The structure also defines how the receptor-cytokine interfaces are affinity tuned to allow distinct signaling through a receptor complex shared by three different ligands. Our results provide unique insights into the complexity of IL-20SFC signaling that may be critical in the design of mechanistic-based inhibitors of IL-20SFC-mediated inflammatory disease.
Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines.,Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. Epub 2012 Jul 16. PMID:22802649[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Logsdon NJ, Deshpande A, Harris BD, Rajashankar KR, Walter MR. Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12704-9. Epub 2012 Jul 16. PMID:22802649 doi:10.1073/pnas.1117551109
