7n3z

Structural highlights

Function

[APN2_YEAST] DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA.^{[1] [2]}

References

1. ↑ Unk I, Haracska L, Johnson RE, Prakash S, Prakash L. Apurinic endonuclease activity of yeast Apn2 protein. J Biol Chem. 2000 Jul 21;275(29):22427-34. PMID:10806210 doi:http://dx.doi.org/10.1074/jbc.M002845200
2. ↑ Johnson RE, Torres-Ramos CA, Izumi T, Mitra S, Prakash S, Prakash L. Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites. Genes Dev. 1998 Oct 1;12(19):3137-43. doi: 10.1101/gad.12.19.3137. PMID:9765213 doi:http://dx.doi.org/10.1101/gad.12.19.3137