Structural highlights
Publication Abstract from PubMed
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.
Intercalative DNA binding of the marine anticancer drug variolin B.,Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M. Intercalative DNA binding of the marine anticancer drug variolin B. Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169 doi:http://dx.doi.org/10.1038/srep39680
