Structural highlights
4mss is a 2 chain structure with sequence from Burcj. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 4gnv, 4g6c |
| Gene: | BCAL1010, BCAL2860, BceJ2315_10000, BceJ2315_27960, nagZ, nagZ1, nagZ2 (BURCJ) |
| Activity: | Beta-N-acetylhexosaminidase, with EC number 3.2.1.52 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Publication Abstract from PubMed
AmpC beta-lactamase confers resistance to beta-lactam antibiotics in many Gram negative bacteria. Inducible expression of AmpC requires an N-acetylglucosaminidase termed NagZ. Here we describe the synthesis and characterization of hydroxyazepane inhibitors of NagZ. We find that these inhibitors enhance the susceptibility of clinically relevant Pseudomonas aeruginosa to beta-lactams.
Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams.,Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Bleriot Y Chem Commun (Camb). 2013 Oct 29;49(93):10983-5. doi: 10.1039/c3cc46646a. PMID:24136176[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Mondon M, Hur S, Vadlamani G, Rodrigues P, Tsybina P, Oliver A, Mark BL, Vocadlo DJ, Bleriot Y. Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to beta-lactams. Chem Commun (Camb). 2013 Oct 29;49(93):10983-5. doi: 10.1039/c3cc46646a. PMID:24136176 doi:http://dx.doi.org/10.1039/c3cc46646a
