3us4

Structural highlights

Function

[MATK_HUMAN] Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.^[1]

See Also

• Tyrosine kinase 3D structures

References

1. ↑ Hirao A, Hamaguchi I, Suda T, Yamaguchi N. Translocation of the Csk homologous kinase (Chk/Hyl) controls activity of CD36-anchored Lyn tyrosine kinase in thrombin-stimulated platelets. EMBO J. 1997 May 1;16(9):2342-51. PMID:9171348 doi:http://dx.doi.org/10.1093/emboj/16.9.2342