2mj7

Structural highlights

Disease

[AP4B1_HUMAN] Severe intellectual deficit and progressive spastic paraplegia. The disease is caused by mutations affecting the gene represented in this entry.

Function

[AP4B1_HUMAN] Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

See Also

• Adaptin 3D structures