Structural highlights
4ruh is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
|
| Ligands: | , , |
| Gene: | CN2, CNDP dipeptidase 2 (metallopeptidase M20 family) [ Homo sapiens (human), CNDP2, CPGL, PEPA (HUMAN) |
| Activity: | Cytosol nonspecific dipeptidase, with EC number 3.4.13.18 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CNDP2_HUMAN] Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.[1] [2]
References
- ↑ Zhang P, Chan DW, Zhu Y, Li JJ, Ng IO, Wan D, Gu J. Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma. Clin Cancer Res. 2006 Nov 15;12(22):6617-25. PMID:17121880 doi:http://dx.doi.org/10.1158/1078-0432.CCR-06-1307
- ↑ Kaur H, Kumar C, Junot C, Toledano MB, Bachhawat AK. Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J Biol Chem. 2009 May 22;284(21):14493-502. doi: 10.1074/jbc.M808952200. Epub, 2009 Apr 3. PMID:19346245 doi:10.1074/jbc.M808952200
