Structural highlights
4tkx is a 1 chain structure with sequence from Atcc 33277. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , , , |
| Gene: | kgp, prtK, prtP (ATCC 33277) |
| Activity: | Gingipain K, with EC number 3.4.22.47 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[KGP83_PORGN] Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria (By similarity).[UniProtKB:B2RLK2]
Publication Abstract from PubMed
The oral pathogen Porphyromonas gingivalis is a keystone pathogen in the development of chronic periodontitis. Gingipains, the principle virulence factors of P. gingivalis are multidomain, cell-surface proteins containing a cysteine protease domain. The lysine specific gingipain, Kgp, is a critical virulence factor of P. gingivalis. We have determined the X-ray crystal structure of the lysine-specific protease domain of Kgp to 1.6 A resolution. The structure provides insights into the mechanism of substrate specificity and catalysis.
Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health.,Gorman MA, Seers CA, Michell BJ, Feil SC, Huq NL, Cross KJ, Reynolds EC, Parker MW Protein Sci. 2015 Jan;24(1):162-6. doi: 10.1002/pro.2589. Epub 2014 Dec 3. PMID:25327141[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Gorman MA, Seers CA, Michell BJ, Feil SC, Huq NL, Cross KJ, Reynolds EC, Parker MW. Structure of the lysine specific protease Kgp from Porphyromonas gingivalis, a target for improved oral health. Protein Sci. 2015 Jan;24(1):162-6. doi: 10.1002/pro.2589. Epub 2014 Dec 3. PMID:25327141 doi:http://dx.doi.org/10.1002/pro.2589
