Structural highlights
4yb4 is a 4 chain structure with sequence from Thet2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , , |
| Gene: | hicd, hdh, hicdh, TT_C1012 (THET2) |
| Activity: | Homoisocitrate dehydrogenase, with EC number 1.1.1.87 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[HICDH_THET2] Catalyzes the NAD(+)-dependent conversion of homoisocitrate to alpha-ketoadipate. In addition, has high activity with citrate, but is inactive with 3-isopropylmalate.[1] [2]
References
- ↑ Miyazaki J, Kobashi N, Nishiyama M, Yamane H. Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase. J Biol Chem. 2003 Jan 17;278(3):1864-71. Epub 2002 Nov 8. PMID:12427751 doi:http://dx.doi.org/10.1074/jbc.M205133200
- ↑ Suzuki Y, Asada K, Miyazaki J, Tomita T, Kuzuyama T, Nishiyama M. Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution. Biochem J. 2010 Oct 11;431(3):401-10. PMID:20735360 doi:10.1042/BJ20101246
