Structural highlights
4zlt is a 4 chain structure with sequence from Cricetid gammaherpesvirus 2 and Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | |
| Related: | 4zkq, 2x6g |
| Gene: | RHVP-L.R17, RHVP.R17 (Cricetid gammaherpesvirus 2), Ccl3, Mip1a, Scya3 (LK3 transgenic mice) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[CCL3_MOUSE] Monokine with inflammatory, pyrogenic and chemokinetic properties. Has a potent chemotactic activity for eosinophils. Binding to a high-affinity receptor activates calcium release in neutrophils.
Publication Abstract from PubMed
A wide variety of pathogens targets chemokine signaling networks in order to disrupt host immune surveillance and defense. Here, we report a structural and mutational analysis of rodent herpesvirus Peru encoded R17, a potent chemokine inhibitor that sequesters CC and C chemokines with high affinity. R17 consists of a pair of beta-sandwich domains linked together by a bridging sheet, which form an acidic binding cleft for the chemokine CCL3 on the opposite face of a basic surface cluster that binds glycosaminoglycans. R17 promiscuously engages chemokines primarily through the same N-loop determinants used for host receptor recognition while residues located in the chemokine 40s loop drive kinetically stable complex formation. The core fold adopted by R17 is unexpectedly similar to that of the M3 chemokine decoy receptor encoded by MHV-68, although, strikingly, neither the location of ligand engagement nor the stoichiometry of binding is conserved, suggesting that their functions evolved independently.
Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors.,Lubman OY, Fremont DH Structure. 2015 Nov 30. pii: S0969-2126(15)00457-8. doi:, 10.1016/j.str.2015.10.018. PMID:26671708[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Lubman OY, Fremont DH. Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors. Structure. 2015 Nov 30. pii: S0969-2126(15)00457-8. doi:, 10.1016/j.str.2015.10.018. PMID:26671708 doi:http://dx.doi.org/10.1016/j.str.2015.10.018
