Structural highlights
5dy3 is a 1 chain structure with sequence from Artan. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , |
| Related: | 5dxx, 5dxy, 5dy2 |
| Gene: | DBR2 (ARTAN) |
| Activity: | Artemisinic aldehyde Delta(11(13)) reductase, with EC number 1.3.1.92 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[DBR2_ARTAN] Involved in the biosynthesis of the antimalarial endoperoxide artemisinin by catalyzing the double bond reduction of (11R)-dihydroartemisinic aldehyde to produce artemisinic aldehyde. Also able to reduce artemisinic alcohol and artemisinic acid to a lesser extent.[1]
References
- ↑ Zhang Y, Teoh KH, Reed DW, Maes L, Goossens A, Olson DJ, Ross AR, Covello PS. The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua. J Biol Chem. 2008 Aug 1;283(31):21501-8. doi: 10.1074/jbc.M803090200. Epub 2008, May 21. PMID:18495659 doi:http://dx.doi.org/10.1074/jbc.M803090200
