Structural highlights
Publication Abstract from PubMed
Quinoline-based oligoamide foldamers have been identified as a potent class of ligands for G-quadruplex DNA. Their helical structure is thought to target G-quadruplex loops or grooves and not G-tetrads. We report a co-crystal structure of the antiparallel hairpin dimeric DNA G-quadruplex (G4 T4 G4 )2 with tetramer 1-a helically folded oligo-quinolinecarboxamide bearing cationic side chains-that is consistent with this hypothesis. Multivalent foldamer-DNA interactions that modify the packing of (G4 T4 G4 )2 in the solid state are observed.
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State.,Mandal PK, Baptiste B, Langlois d'Estaintot B, Kauffmann B, Huc I Chembiochem. 2016 Oct 17;17(20):1911-1914. doi: 10.1002/cbic.201600281. Epub 2016, Aug 19. PMID:27472456[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Mandal PK, Baptiste B, Langlois d'Estaintot B, Kauffmann B, Huc I. Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G-Quadruplex in the Solid State. Chembiochem. 2016 Oct 17;17(20):1911-1914. doi: 10.1002/cbic.201600281. Epub 2016, Aug 19. PMID:27472456 doi:http://dx.doi.org/10.1002/cbic.201600281
