Pertussis toxin

From Proteopedia

spinqualitylabelsall models Pertussis toxin (PDB entry 1prt) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Pertussis toxin (PT) is produced by the bacterium Bordetella pertussis and is the cause of whooping cough[1]. For additional details see Pertussis Toxin-ATP Complex. Pertactin is another toxin produced by Bordetella. For details see P.69 Pertactin Structure and Function. Relevance PT is associated with exacerbated host airway response during whooping cough infection and may inhibit host mechanisms of attenuating inflammation of the airways[2].

3D Structures of Pertussis toxin

1prt – BpPT - Bordetella pertussis
1pto – BpPT + galactose
1bcp – BpPT + ATP
6ro0 – BpPT 1,2,5 subunits + islet-activating protein S2 + islet-activating protein S3 + islet-activating protein S4

Pertactin

1dab - BpPer
2iou - Per extracellular domain + major tropism determinant - Bordetella bronchiseptica

References

1. ↑ Carbonetti NH, Artamonova GV, Andreasen C, Bushar N. Pertussis toxin and adenylate cyclase toxin provide a one-two punch for establishment of Bordetella pertussis infection of the respiratory tract. Infect Immun. 2005 May;73(5):2698-703. PMID:15845471 doi:http://dx.doi.org/10.1128/IAI.73.5.2698-2703.2005
2. ↑ Connelly CE, Sun Y, Carbonetti NH. Pertussis toxin exacerbates and prolongs airway inflammatory responses during Bordetella pertussis infection. Infect Immun. 2012 Dec;80(12):4317-32. doi: 10.1128/IAI.00808-12. Epub 2012 Oct, 1. PMID:23027529 doi:http://dx.doi.org/10.1128/IAI.00808-12