4jjr

Structural highlights

Function

KC1D_MOUSE Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2, leading to retain PER1 in the cytoplasm. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.^{[1] [2] [3] [4] [5] [6] [7]}

See Also

• Casein kinase 3D structures

References

1. ↑ Chergui K, Svenningsson P, Greengard P. Physiological role for casein kinase 1 in glutamatergic synaptic transmission. J Neurosci. 2005 Jul 13;25(28):6601-9. PMID:16014721 doi:10.1523/JNEUROSCI.1082-05.2005
2. ↑ Wolff S, Stoter M, Giamas G, Piesche M, Henne-Bruns D, Banting G, Knippschild U. Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin. FEBS Lett. 2006 Nov 27;580(27):6477-84. Epub 2006 Nov 7. PMID:17101137 doi:10.1016/j.febslet.2006.10.068
3. ↑ Etchegaray JP, Machida KK, Noton E, Constance CM, Dallmann R, Di Napoli MN, DeBruyne JP, Lambert CM, Yu EA, Reppert SM, Weaver DR. Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66. doi: 10.1128/MCB.00338-09. Epub 2009 May , 4. PMID:19414593 doi:10.1128/MCB.00338-09
4. ↑ Lee H, Chen R, Lee Y, Yoo S, Lee C. Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21359-64. doi:, 10.1073/pnas.0906651106. Epub 2009 Nov 30. PMID:19948962 doi:10.1073/pnas.0906651106
5. ↑ Sugiyama Y, Hatano N, Sueyoshi N, Suetake I, Tajima S, Kinoshita E, Kinoshita-Kikuta E, Koike T, Kameshita I. The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon. Biochem J. 2010 Apr 14;427(3):489-97. doi: 10.1042/BJ20091856. PMID:20192920 doi:10.1042/BJ20091856
6. ↑ Etchegaray JP, Yu EA, Indic P, Dallmann R, Weaver DR. Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One. 2010 Apr 22;5(4):e10303. doi: 10.1371/journal.pone.0010303. PMID:20421981 doi:10.1371/journal.pone.0010303
7. ↑ Zhou M, Rebholz H, Brocia C, Warner-Schmidt JL, Fienberg AA, Nairn AC, Greengard P, Flajolet M. Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4401-6. doi: 10.1073/pnas.0915173107., Epub 2010 Feb 9. PMID:20145109 doi:10.1073/pnas.0915173107
8. ↑ Zeringo NA, Murphy L, McCloskey EA, Rohal L, Bellizzi JJ 3rd. A monoclinic crystal form of casein kinase 1 delta Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Oct 1;69(Pt 10):1077-1083., Epub 2013 Sep 28. PMID:24100552 doi:http://dx.doi.org/10.1107/S1744309113023403